解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Innate lymphoid cells (ILCs) of the ILC22 type protect the intestinal mucosa from infection by secreting interleukin 22 (IL-22). ILC22 cells include NKp46(+) and lymphoid tissue-inducer (LTi)-like subsets that express the aryl hydrocarbon receptor (AHR). Here we found that Ahr(-/-) mice had a considerable deficit in I...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2187
更新日期:2011-11-20 00:00:00
abstract::Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2159
更新日期:2011-11-16 00:00:00
abstract::Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell d...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2154
更新日期:2011-11-13 00:00:00
abstract::Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2157
更新日期:2011-11-06 00:00:00
abstract::Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The RNase regnase-1 serves a critical role in preventing autoimmunity by controlling the stability of mRNAs that encode cytokines. Here we...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2137
更新日期:2011-10-30 00:00:00
abstract::The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradati...
journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2115
更新日期:2011-09-20 00:00:00
abstract::Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it see...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2060
更新日期:2011-07-19 00:00:00
abstract::The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2064
更新日期:2011-07-03 00:00:00
abstract::Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2051
更新日期:2011-06-12 00:00:00
abstract::Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an in...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2018
更新日期:2011-06-01 00:00:00
abstract::The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...
journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2042
更新日期:2011-06-01 00:00:00
abstract::Helper T cells control host defense against pathogens. The receptors for interleukin 12 (IL-12), IL-4 and IL-6 are required for differentiation into the T(H)1, T(H)2 and T(H)17 subsets of helper T cells, respectively. IL-2 signaling via the transcription factor STAT5 controls T(H)2 differentiation by regulating both t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2030
更新日期:2011-06-01 00:00:00
abstract::T cell exhaustion has a major role in failure to control chronic infection. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we demonstrate that the t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2046
更新日期:2011-05-29 00:00:00
abstract::Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2033
更新日期:2011-05-22 00:00:00
abstract::High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2022
更新日期:2011-05-01 00:00:00
abstract::Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1983
更新日期:2011-02-01 00:00:00
abstract::The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1957
更新日期:2010-12-01 00:00:00
abstract::Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells. ...
journal_title:Nature immunology
pub_type: 评论,杂志文章,评审
doi:10.1038/ni1210-1079
更新日期:2010-12-01 00:00:00
abstract::Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. One therapy for type 2 diabetes, g...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1935
更新日期:2010-10-01 00:00:00
abstract::Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1937
更新日期:2010-10-01 00:00:00
abstract::Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strat...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1916
更新日期:2010-09-01 00:00:00
abstract::Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...
journal_title:Nature immunology
pub_type:
doi:10.1038/ni0910-769
更新日期:2010-09-01 00:00:00
abstract::Viral infection induces type I interferons (IFN-alpha and IFN-beta) that recruit unexposed cells in a self-amplifying response. We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activity. MafB acted as a weak positive basal regulator of transcription at the IFNB1 promoter t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1897
更新日期:2010-08-01 00:00:00
abstract::A fundamental puzzle in immunology is how the immune system decides what types of immune responses to launch against different stimuli. Although much is known about control of T helper type 1 (T(H)1) and T(H)17 responses, the mechanisms that initiate T(H)2 and T regulatory (T(reg)) responses remain obscure. Emerging s...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1894
更新日期:2010-08-01 00:00:00
abstract::The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1883
更新日期:2010-07-01 00:00:00
abstract::Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1869
更新日期:2010-06-01 00:00:00
abstract::Most antigenic peptides presented by major histocompatibility complex (MHC) class I molecules are produced by the proteasome. Here we show that a proteasome-independent peptide derived from the human tumor protein MAGE-A3 is produced directly by insulin-degrading enzyme (IDE), a cytosolic metallopeptidase. Cytotoxic T...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1862
更新日期:2010-05-01 00:00:00
abstract::The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR ne...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1860
更新日期:2010-05-01 00:00:00
abstract::The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of na...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1793
更新日期:2009-12-01 00:00:00
abstract::Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1814
更新日期:2009-12-01 00:00:00
abstract::The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1789
更新日期:2009-11-01 00:00:00
abstract::More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1009-1039
更新日期:2009-10-01 00:00:00
abstract::Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to disti...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1778
更新日期:2009-10-01 00:00:00
abstract::Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching. ...
journal_title:Nature immunology
pub_type: 新闻
doi:10.1038/ni0909-933
更新日期:2009-09-01 00:00:00
abstract::Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1772
更新日期:2009-09-01 00:00:00
abstract::DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of beta-catenin. ...
journal_title:Nature immunology
pub_type: 新闻
doi:10.1038/ni0709-681
更新日期:2009-07-01 00:00:00
abstract::By genetically ablating IkappaB kinase (IKK)-mediated activation of the transcription factor NF-kappaB in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin lambda-chain-positive B cells are generated in the absence of rearrangements in the locus encoding immunoglobulin kappa-chain, we define h...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1732
更新日期:2009-06-01 00:00:00
abstract::High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) foll...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1715
更新日期:2009-04-01 00:00:00
abstract::An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1706
更新日期:2009-04-01 00:00:00
abstract::The Fc receptor common gamma-chain (FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRgamma developed normally and proliferated efficiently in response to inter...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1686
更新日期:2009-02-01 00:00:00